Preimplantation Genetic Testing (PGT)
What is Preimplantation Genetic Testing?
Preimplantation genetic testing helps in identifying defects of genetics in the embryos. PGT has become an integral part of Assisted Reproductive Technology. With this test, doctors diagnose if there is any genetic disease in the person. It helps to avoid the passing of any genetic condition to the child.
Only unaffected embryos are allowed to transfer for implantation in the uterus. It is to be remembered that negative PGT tests don’t guarantee that the newborn will take birth with zero birth defects.
Preimplantation Genetic Testing (PGT)
There are two different testings under PGT. These are Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD)
Difference Between PGD And PGS
Preimplantation genetic diagnosis (PGD) helps to determine if the baby to be born of the embryo is also carrying the genetic abnormalities that are running in the family. It applies to situations where parents have a known genetic abnormality. If a family has a history of muscular dystrophy, sickle cell anemia, and cystic fibrosis, doctors recommend this test for them.
A PGD is done to check for a genetic condition in an embryo when it is known that both or one genetic parent has some genetic abnormality.
Whereas, Preimplantation genetic screening (PGS) applies to the couple with normal genes, but the embryo has a chromosomal abnormality. It is done to screen the embryo in order to check if there’s any genetic abnormality in an embryo before the transfer.
Preimplantation genetic testing involves the following steps:
It starts with the process of in vitro fertilization. In a laboratory, egg retrieval and fertilization will be done. The cell division of the embryos will start within the next three to five days. After this,
- The doctor removes a few cells from the embryo by laser biopsy and then freezes the embryos.
- After this, they evaluate the cells for determining the inheritance of a problematic gene in the embryo. It takes ten to twenty days.
- After the identification of genetic problems free embryo, the doctors will place it in the uterus.
- They freeze and keep the healthy embryos for the later pregnancy. It takes some weeks. It can take several weeks for getting the final results.
What are the Advantages of preimplantation genetic diagnosis?
There are some advantages of PGD which include the following.:
- With the test of PGD, doctors can detect hundreds of abnormal conditions of the gene. They can offer this to families with a history of single genetic defects which include sickle cell anemia, cystic fibrosis, and muscular dystrophy.
- The doctor performs this procedure before transferring and implanting the embryo and allows the couple to think about the pregnancy.
- It increases the chances of a healthy pregnancy by screening and diagnosing all kinds of genetic abnormalities.
What are the Disadvantages of PGD?
- PGD cannot remove the risk of conceiving a child with the genetic disorder completely, but it can only reduce the risk.
- With some genetic diseases, the carrier can develop the symptoms in their middle age. Then you need to discuss it with your doctor or physician.
Is PGS Right for me?
The doctors recommend this test for the parents who have no abnormalities in the gene. The other conditions are that the age of the woman needs to be thirty-eight years or more, the couple must be interested in transferring a single embryo and have a history of failed IVF or miscarriage or failed implementation. In such cases, the doctor may recommend PGS to you.
Is embryo biopsy, PGD, and PGS safe?
If you want to know about the safety of PGD, embryo biopsy, and PGS, the answer is yes. According to the result of PGD in animals and several human live births, PGD has no record of increasing birth defects. The alteration between the removal of trophectoderm cells of the early embryo and the development of the embryo’s ability into normal pregnancy is not possible.
You need to take or consult a genetic counsellor or doctor if you are considering testing PGD.
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Rohit Krishna Gupta
Had a great experience with Dr. Gunjan. We visited the clinic as we had some queries regarding the conception process. Dr. Gunjan listened to the queries and answered all those with patience. And we had good news at the next consultation itself. Dr. Gunjan is very experienced, is soft-spoken, and very diligent with the process. Highly recommended!
Know the Expert before you visit our clinic
A team of Specialists working together as a team with a single Goal: Patient Satisfaction
Dr. Gunjan Gupta Govil
MRCOG(UK), MD(Gynae) – Founder & CEO
She is a Gynaecologist with specialization in IVF, Infertility & Laparoscopy specialist doctor and has close to 2 decades of experience in treating Infertility, performing Gynae Laparoscopy (Keyhole Surgeries) & Handing high-risk Pregnancies. She is a noted speaker in National and International level conferences and has also chaired various sessions on Infertility
- 86% (218 Votes)
- 86% (218 Votes)
- 86% (218 Votes)
Dr. Pradyot Kumar
Dr. Pradyot Kumar is the founder and CEO of Gunjan IVF World. He is a Neurosurgeon with specialization
(20+ years of experience)
Mr. Gaurav Singhai
Co-Founder & COO
He has 15 years of Managerial Experience from various National & International Organizations like TCS, Fiserv & Sopra Steria. He has lived and worked with various MNCs in the US, UK, France & The Netherlands and gained immense experience and skills which he now contributes to Gunjan’s IVF World assiduously.
Dr. Abhishek Parihar
He is a dedicated & experienced Gynaecologist offering comprehensive fertility practice oriented towards fertility treatment. He has vast experience in dealing with infertile couples and providing health care assistance to them during course of their treatment.
He is a highly experienced and successful Embryologist with more than 10 years of experience in IVF. He has done M.Sc. in Biotechnology from MIMS, Jaipur. He has done more than 4000 IVFs and 3000+ ICSI cases till date.)
Dr. Arshi khan
She is another proud member of our medical team & while serving as a RMO for the past few years, she assists Dr. Gunjan during her session with various patients. Moreover, She is a graduate in BUMS and aspire to achieve greater heights in her career in the future.
Ms. Nivedita Rai
She is the Head Counselor at Gunjan IVF world who counsels and coordinates with our patients during the course of their treatment. Patients hold a very high regard for her. She has pursued her MBA from IMT Ghaziabad & been a part of our Gunjan IVF world Family since past many years.
We not just treat our patient, we also guide them throughout all medical terms and their problems
Do you know the success rate of pregnancy with the IUI procedures ranges from 15% to 20% per cycle? Yes, this is true. IUI, which is Intrauterine insemination, is a kind of artificial insemination that helps in treating infertility issues. This a quick process in which the pre-selected sperm is directly injected into your uterus or womb.
IUI or Intrauterine insemination is a less invasive procedure when compared to IVF or In vitro fertilization. Couples get many benefits from this procedure as the chances of pregnancy increase a lot because of IUI.
The reasons for an unsuccessful implantation are very uncommon and rare as well. Blastocyst provides a greater chance of becoming pregnant therefore the procedure is handled properly as well.
Before jumping to the immediate question first let’s have a small brief of what is blastocyst transfer. Blastocyst transfer is the transfer of embryos that have achieved a higher stage of development.
Normally in natural pregnancy, when a period cycle starts, an egg gets matured in the ovaries. When it becomes 18-20 mm then it is released at that time. After a physical relationship between a couple, the sperms fertilize this mature egg in the fallopian tube. Once the fertilization occurs, this fertilized egg converts into an embryo and sticks to the uterus that causes pregnancy.
If we talk about the term “Secondary Infertility” it generally refers to a situation when a woman is going through certain infertility issues even after carrying a baby already in her life. Moreover, this type of Infertility results in almost 50 percent of total infertility cases in women around the world. This is most common in couples who think of having a baby in their late 30s and 40s.
Egg freezing, medically known as human oocyte cryopreservation. It is an effective procedure allows the woman to go against the biological clock. It enables women to postpone pregnancy to a later date. In this phenomenon, eggs extracted, frozen and stored. The success rate of the procedure depends on the age of the woman and ranges from approximately 14% to 30%.