Preimplantation Genetic Testing (PGT)
What is Preimplantation Genetic Testing?
Preimplantation genetic testing helps in identifying defects of genetics in the embryos. PGT has become an integral part of Assisted Reproductive Technology. With this test, doctors diagnose if there is any genetic disease in the person. It helps to avoid the passing of any genetic condition to the child.
Only unaffected embryos are allowed to transfer for implantation in the uterus. It is to be remembered that negative PGT tests don’t guarantee that the newborn will take birth with zero birth defects.
Preimplantation Genetic Testing (PGT)
There are two different testings under PGT. These are Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD)
Difference Between PGD And PGS
Preimplantation genetic diagnosis (PGD) helps to determine if the baby to be born of the embryo is also carrying the genetic abnormalities that are running in the family. It applies to situations where parents have a known genetic abnormality. If a family has a history of muscular dystrophy, sickle cell anemia, and cystic fibrosis, doctors recommend this test for them.
A PGD is done to check for a genetic condition in an embryo when it is known that both or one genetic parent has some genetic abnormality.
Whereas, Preimplantation genetic screening (PGS) applies to the couple with normal genes, but the embryo has a chromosomal abnormality. It is done to screen the embryo in order to check if there’s any genetic abnormality in an embryo before the transfer.
Preimplantation genetic testing involves the following steps:
It starts with the process of in vitro fertilization. In a laboratory, egg retrieval and fertilization will be done. The cell division of the embryos will start within the next three to five days. After this,
- The doctor removes a few cells from the embryo by laser biopsy and then freezes the embryos.
- After this, they evaluate the cells for determining the inheritance of a problematic gene in the embryo. It takes ten to twenty days.
- After the identification of genetic problems free embryo, the doctors will place it in the uterus.
- They freeze and keep the healthy embryos for the later pregnancy. It takes some weeks. It can take several weeks for getting the final results.
What are the Advantages of preimplantation genetic diagnosis?
There are some advantages of PGD which include the following.:
- With the test of PGD, doctors can detect hundreds of abnormal conditions of the gene. They can offer this to families with a history of single genetic defects which include sickle cell anemia, cystic fibrosis, and muscular dystrophy.
- The doctor performs this procedure before transferring and implanting the embryo and allows the couple to think about the pregnancy.
- It increases the chances of a healthy pregnancy by screening and diagnosing all kinds of genetic abnormalities.
What are the Disadvantages of PGD?
- PGD cannot remove the risk of conceiving a child with the genetic disorder completely, but it can only reduce the risk.
- With some genetic diseases, the carrier can develop the symptoms in their middle age. Then you need to discuss it with your doctor or physician.
Is PGS Right for me?
The doctors recommend this test for the parents who have no abnormalities in the gene. The other conditions are that the age of the woman needs to be thirty-eight years or more, the couple must be interested in transferring a single embryo and have a history of failed IVF or miscarriage or failed implementation. In such cases, the doctor may recommend PGS to you.
Is embryo biopsy, PGD, and PGS safe?
If you want to know about the safety of PGD, embryo biopsy, and PGS, the answer is yes. According to the result of PGD in animals and several human live births, PGD has no record of increasing birth defects. The alteration between the removal of trophectoderm cells of the early embryo and the development of the embryo’s ability into normal pregnancy is not possible.
You need to take or consult a genetic counsellor or doctor if you are considering testing PGD.
It’s always the word of mouth that’s the best advice
Rohit Krishna Gupta
Had a great experience with Dr. Gunjan. We visited the clinic as we had some queries regarding the conception process. Dr. Gunjan listened to the queries and answered all those with patience. And we had good news at the next consultation itself. Dr. Gunjan is very experienced, is soft-spoken, and very diligent with the process. Highly recommended!
Know the Expert before you visit our clinic
A team of Specialists working together as a team with a single Goal: Patient Satisfaction
Dr. Gunjan Gupta Govil
MRCOG(UK), MD(Gynae) – Founder & Director
She is a Gynaecologist with specialization in IVF, Infertility & Laparoscopy specialist doctor and has close to 2 decades of experience in treating Infertility, performing Gynae Laparoscopy (Keyhole Surgeries) & Handing high risk Pregnancies. She is a noted speaker in National and International level conferences and has also chaired various sessions on Infertility
- 4.5 (267 Votes)
- 4.5 (261 Votes)
- 3.5 (199 Votes)
Dr. Pradyot Kumar
Dr. Pradyot Kumar is the CEO of Gunjan IVF World. He is a Neurosurgeon with specialization
(20+ years of experience)
Mr. Gaurav Singhai
Co-Founder & COO
He has 15 years of Managerial Experience from various National & International Organizations like TCS, Fiserv & Sopra Steria. He has lived and worked with various MNCs in the US, UK, France & The Netherlands and gained immense experience and skills which he now contributes to Gunjan’s IVF World assiduously.
Dr Ankita Nigam, MS
MS Obs & Gynae (Gold Medallist). Dr Ankita Nigam has 3+ years of experience in IVF, Infertility and Gynaecology. She conducts and assists in OPD at our Indirapuram and Meerut centres. She actively assists IVF consultants in all procedures. She takes care of the management of various IVF, Infertility, Pregnancy care patients. She has done a special training in "Ultrasound Whole abdomen and Obstetrics & Gynaecology" from Thomas Jefferson University Philadelphia US.
Dr. Rajeshwari Suthar
Dr Rajeshwari Suthar has 5+ years of experience in IVF & Infertility treatments. She actively assists our IVF consultants in OPDs. She is an excellent counsellor and patients are very comfortable with her. She has done BHMS from Hemchandracharya University, Gujarat in 2011.
He is a highly experienced and successful Embryologist with more than 10 years of experience in IVF. He has done M.Sc. in Biotechnology from MIMS, Jaipur. He has done more than 4000 IVFs and 3000+ ICSI cases till date.)
Ms. Nivedita Rai
MBA in HR from IMT Ghaziabad B.Ed, M.SC in psychology (pursuing). Nivedita Rai is our Head counsellor. She has been with Gunjan IVF World for the last 4.5 years. Her mission as a Head Counsellor is to bring happiness to all those who are unable to conceive. She makes them understand the various infertility treatments that we offer and help them throughout their journey to parenthood. She is a project Head of children welfare related projects of NGO Develop India Foundation and She is also a Reiki practitioner.
We not just treat our patient, we also guide them throughout all medical terms and their problems
The reasons for an unsuccessful implantation are very uncommon and rare as well. Blastocyst provides a greater chance of becoming pregnant therefore the procedure is handled properly as well.
Before jumping to the immediate question first let’s have a small brief of what is blastocyst transfer. Blastocyst transfer is the transfer of embryos that have achieved a higher stage of development.
Maximum patients worry about what they can do or cannot do after an embryo transfer. They have the fear that if they do something wrong, the embryo would not attach or fall out.
Whether you want to conceive naturally or through IVF, the best period is between 20-30 years to get pregnant. During this time, women have the best fertility potential. Also, during this period the quantity and quality of the eggs or ovarian reserve is also good. As compared to men, increasing age affects women’s fertility a lot. If your age is between 25-30 years, the chances of getting pregnant with a single menstrual cycle are 25%. And as soon as your age increases, these pregnancy chances drop to just 5% when you reach 50.
IUI stands for Intrauterine insemination or also known as artificial insemination. In this method, semen is washed and placed inside the uterine cavity so once the ovulation occurs or the egg is released the sperm will fertilise the egg.
The couple has to undergo certain IVF treatment evaluations. These are the blood test before IVF. IVF tests for Females: The female has to undergo several tests such as female hormonal tests, egg count and quality assessment, blood tests such as AMH, prolactin, thyroid & basic tests such as hemoglobin, sugar, etc. ultrasound is done to check the uterus.
Although a lot has been quoted and stated about mental health and its role in Infertility issues amongst couples around, the fact still says that Psychological stress doesn’t result in Infertility. Still a number of medical studies in the same regard state that mental health plays a negative role in the overall pregnancy chances for a particular person. It doesn’t matter if you are going through physical or mental stress, it can’t be considered as “Useful” for the fertility period by any means.
Mini IVF is also called micro or minimal stimulation IVF. It follows the same pattern as in conventional IVF i.e. retrieval of the egg, fertilization of sperm and egg in simulated laboratory conditions finally followed by embryo transfer.
Planning your visit to an IVF center in order to sort out your infertility issues can sometimes become a tedious task with all the unwanted stress and nervousness. It will take long time for the patients to prepare themselves mentally before consulting an IVF specialist. It Obvious as they would be carrying thousands of questions along with all that curiosity in their mind